Philadelphia 76ers vs Cleveland Cavaliers Preview and Prediction - Nov. 5 | 2025-26 NBA Season

The Philadelphia 76ers roundup their three-game road trip when they face the Cleveland Cavaliers in another round of league games. It is one of the 11 games scheduled for Wednesday.

The Sixers are 5-2 to start the season. They lost their last game, 113-111 against the Chicago Bulls on Tuesday.

Philadelphia guard Tyrese Maxey recorded 39 points, five rebounds and five assists. Center Joel Embiid added 20 points, six rebounds and two assists.

The Cavaliers, on the other hand, have a 4-3 record. They snapped a two-game losing streak on Sunday, winning 117-109 against the Atlanta Hawks at home.

Donovan Mitchell recorded 37 points, two rebounds and five assists. De'Andre Hunter added 18 points, seven rebounds and three assists.

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Philadelphia 76ers vs. Cleveland Cavaliers game details

The Sixers-Cavs game is scheduled for 7 p.m. ET at the Rocket Arena, in Cleveland, Ohio. The matchup will air on TV on FanDuel Sports Network Ohio, FanDuel Sports Network App, Rock Entertainment Sports Network (channel 43 in Cleveland) and NBA League Pass. Fans can stream the same on Fubo.

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Philadelphia 76ers vs. Cleveland Cavaliers betting lines

Moneyline: Sixers (+310) vs. Cavaliers (-390)

Spread: Sixers (+10.0) vs. Cavaliers (-10.0)

Total: (O/U): Sixers (o234.0) -110 vs. Cavaliers (u234.0) -110

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Philadelphia 76ers vs. Cleveland Cavaliers preview

The Sixers have a better head-to-head record against the Cavs. They have met 230 times and Philadelphia leads with a 119-111 record. However, in their last 10 matchups, both teams are evenly split at 5-5.

Their last matchup was on Jan. 24, with the Sixers winning 132-129 at home. Philadelphia forward Paul George recorded 30 points, five rebounds and three assists. Cleveland guard Mitchell finished with 37 points, three rebounds and seven assists.

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Philadelphia 76ers vs. Cleveland Cavaliers predicted starting lineups

Sixers

PG - Tyrese Maxey | SG - VJ Edgecombe | SF - Kelly Oubre Jr. | PF - Trendon Watford | C - Joel Embiid

Cavaliers

PG: Lonzo Ball | SG: Donovan Mitchell | SF: De'Andre Hunter | PF: Evan Mobley | C: Larry Nance Jr.

Note: The starting lineups could still change ahead of tipoff.

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Philadelphia 76ers vs. Cleveland Cavaliers betting tips

Tyrese Maxey has an over/under of 30.5 points via FanDuel. He is averaging 34.4 ppg this season, and the safe bet is the under.

Meanwhile, Donovan Mitchell has an over/under of 25.5 points via FanDuel. He is averaging 29.5 ppg this season, and the safe bet is the over.

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Game prediction

The Sixers-Cavs matchup will see both teams come in with a chance at leaving with a win. However, Cleveland is the bookmaker's favorite to win this matchup. With a 79.6% win percentage compared to the Sixers’ 24.4%.