Philadelphia 76ers vs Detroit Pistons Prediction and Preview - Nov. 14 | 2025 NBA Cup

The Philadelphia 76ers will face the Detroit Pistons at Little Caesars Arena for a quick one-game road trip before returning home for a two-game stretch. Friday’s matchup will be the second of four meetings between the two Eastern Conference rivals, with the Pistons holding a 1-0 lead in the season series.

Philadelphia 76ers vs. Detroit Pistons Preview, Odds, Betting Tips and Prediction

The 76ers-Pistons NBA Cup clash is set to tip off at 7:30 p.m. ET (4:30 p.m. PT). The live telecast will be available on FDSDET and NBCS-PH. Fans can watch the contest via livestream on NBA League Pass and Fubo TV (restrictions may apply).

Moneyline: 76ers (+180) vs Pistons (-218)

Odds: 76ers (+5.5 -110) vs Pistons (-5.5 -110)

Total (O/U): 76ers (o232.5 -115) vs Pistons (u232.5 -110)

Editor’s Note: The odds could change closer to the game. The odds listed are based on available information at the time of publication.

Philadelphia 76ers vs. Detroit Pistons Preview

Even without Joel Embiid and Paul George for the majority of the season, the Philadelphia 76ers have managed to hold their ground. Tyrese Maxey has been the biggest difference maker, averaging 32.1 points and 8.3 assists per game, which has led the team to a 7-4 start.

Detroit has exceeded expectations, boasting the best record in the Eastern Conference at 10-2. That run includes an eight-game winning streak, with one of those victories coming against the 76ers.

Maxey led all scorers with 33 points that night. However, Cade Cunningham’s 26 points and 11 assists, along with Jalen Duren’s 21-point, 16-rebound double-double, helped Detroit clinch a 111-108 win.

Philadelphia 76ers vs. Detroit Pistons Predicted Starting 5s

76ers starting 5

G: Tyrese Maxey | G: VJ Edgecombe | F: Kelly Oubre Jr. | F: Trendon Watford | C: Andre Drummond

Pistons starting 5

G: Cade Cunningham | G: Duncan Robinson | F: Javonte Green | F: Ronald Holland II | C: Jalen Duren

Philadelphia 76ers vs. Detroit Pistons betting tips

Cade Cunningham O/U 28.5 points - Take the over

Tyrese Maxey O/U 29.5 points - Take the over

Jalen Duren O/U 13.5 rebounds - Take the under

Kelly Oubre Jr. O/U 15.5 points - Take the under

Philadelphia 76ers vs. Detroit Pistons Predictions

The Detroit Pistons are playing with a lot of confidence right now, and the short-handed 76ers might struggle to keep up. Detroit has also been excellent at home, boasting a 5-1 record at Little Caesars Arena, which gives them an edge in this matchup.

Prediction: Expect the Pistons to win by nine points.