Indiana Pacers vs Philadelphia 76ers Prediction and Betting Tips - Dec. 12 | 2025-2026 NBA Season

The Philadelphia 76ers will conclude their two-game homestand with a contest against the Indiana Pacers. Friday’s game at Xfinity Mobile Arena marks the first of four meetings between the two Eastern Conference rivals during the 2025-2026 regular season.

Indiana Pacers vs. Philadelphia 76ers Preview, Odds, Betting Tips and Prediction

The Pacers-Sixers clash is set to tip off at 7 p.m. ET (4 p.m. PT). The live telecast will be available on FanDuel Sports Network Indiana. Fans can watch the contest via livestream on NBA League Pass and Fubo TV (restrictions may apply).

Moneyline: Pacers (+230) vs Sixers (-272)

Odds: Pacers +6.5 (-105) vs Sixers -6.5 (-115)

Total (O/U): O229.5 (-115) vs U229.5 (-110)

Editor’s Note: The odds could change closer to the game. The odds listed are based on available information at the time of publication.

Indiana Pacers vs. Philadelphia 76ers Preview

The Indiana Pacers have clearly struggled in Tyrese Haliburton’s absence, sitting 14th in the Eastern Conference at 6-18. However, their recent form has been far more encouraging. They have picked up four wins in their last six games and head into Friday’s matchup riding a two-game winning streak.

Philadelphia, meanwhile, finds itself sixth in the East. Even with Joel Embiid and Paul George missing most of the season due to injuries, Tyrese Maxey has led the 76ers to a 13-10 record. During this run, Philly has also clinched impressive victories against strong opponents, including the Boston Celtics, Toronto Raptors, Orlando Magic, and Golden State Warriors.

Indiana Pacers vs. Philadelphia 76ers Predicted Starting 5s

Pacers Starting 5

G: Andrew Nembhard | G: Ethan Thompson | F: Bennedict Mathurin | F: Pascal Siakam | C: Jay Huff

76ers Starting 5

G: Tyrese Maxey | G: VJ Edgecomb | F: Jabari Walker | F: Paul George | C: Joel Embiid

Indiana Pacers vs. Philadelphia 76ers Betting Tips

• Tyrese Maxey O/U 28.5 points - Take the under
• Pascal Siakam O/U 6.5 rebounds - Take the over
• T.J. McConnell O/U 4.5 assists - Take the over
• Bennedict Mathurin O/U 21.5 points - Take the under

Indiana Pacers vs. Philadelphia 76ers Prediction

The Pacers are riding a two-game winning streak, but those victories came against teams that are not as strong as the Sixers. Philadelphia appears to have the edge in this matchup, due to the star power across their roster and the depth of their scoring options. From the starters to bench contributors like Jared McCain and Quentin Grimes, the Sixers have too many offensive threats for Indiana to contain.

Prediction: Expect the Sixers to win by nine points.