Indiana Pacers vs Cleveland Cavaliers Preview and Prediction - Nov. 21 | 2025 NBA Emirates Cup

The Indiana Pacers will be on the road to face the Cleveland Cavaliers in another round of NBA Cup games on Friday.

The Pacers are 14th in the Eastern Conference with a 2-13 record. They snapped an eight-game losing streak on Wednesday, defeating the Charlotte Hornets 127-118 on home court.

Pacers forward Bennedict Mathurin recorded 24 points, 12 rebounds and two assists. Pascal Siakam added 22 points, four rebounds and seven assists.

The Cavaliers, on the other hand, are fourth in the East with a 10-6 record. They have won three of their last five games, but are coming off a 114-104 home loss against the Houston Rockets on Wednesday.

Donovan Mitchell recorded 21 points, three rebounds and two assists. De'Andre Hunter chipped in with 25 points, four rebounds and two assists.

---

Indiana Pacers vs. Cleveland Cavaliers game details

The Pacers-Cavaliers game is scheduled for 7 pm ET at Rocket Arena in Cleveland, Ohio. The matchup can be watched on Amazon Prime Video.

---

Indiana Pacers vs. Cleveland Cavaliers betting lines

Moneyline: Pacers (+525) vs. Cavaliers (-750)

Spread: Pacers (+12.5) vs. Cavaliers (-12.5)

Total: (O/U): Pacers (o238.5) -110 vs. Cavaliers (u238.5) -110

---

Indiana Pacers vs. Cleveland Cavaliers preview

The two teams have met 215 times, and Indiana leads 111-104. The Pacers have also dominated their last 10 contests against the Cavaliers, posting a 7-3 record.

Their last matchup was on May 13 in Game 5 of the Eastern Conference semifinals. Indiana won 114-104 on the road. Mitchell recorded 35 points, nine rebounds and one assist. Tyrese Haliburton finished with 31 points, six rebounds and eight assists.

---

Indiana Pacers vs. Cleveland Cavaliers predicted starting lineups

Pacers

PG: Andrew Nembhard | SG: Bennedict Mathurin | SF: Ben Sheppard | PF: Pascal Siakam | C: Isaiah Jackson

Cavaliers

PG - Craig Porter Jr. | SG - Donovan Mitchell | SF - De'Andre Hunter | PF - Evan Mobley | C - Thomas Bryant

Note: The starting lineups could still change ahead of tipoff.

---

Indiana Pacers vs. Cleveland Cavaliers betting tips

Bennedict Mathurin has an over/under of 21.5 points via FanDuel. He is averaging 27.8 ppg this season, and the safe bet is the over.

Meanwhile, Donovan Mitchell has an over/under of 28.5 points via FanDuel. He is averaging 30.2 ppg this season, and the safe bet is the over.

---

Game prediction

The Cavaliers are huge favorites to beat the Pacers. They have an 88.2% win probability compared to the Pacers' 16%. Expect Cleveland to walk away with a comfortable win, beating the 12.5-point spread.