The upcoming episode of WWE SmackDown will be the final show before Saturday Night's Main Event. Major matches for SNME have already been announced, and this episode will give the final push to the entire storyline.In this article, we will be looking at five things that could happen on the blue brand before the NBC special event.#5. Tiffany Stratton could be forced to vacate the title due to injuryLast week, Tiffany Stratton suffered a massive betrayal from Jade Cargill when The Storm turned heel and attacked the WWE Women's Champion. After the attack, WWE announced that Stratton's knee is being evaluated, and there has been no update since then.This storyline could further develop in the upcoming episode of the Friday Night Show, when Nick Aldis may force Tiffany to vacate the title due to storyline injury. This angle will help the company establish Jade Cargill as a ruthless heel star.For those unaware, Tiffany is already set to defend her Women's Championship at SNME against Jade Cargill.#4. Nikki Cross could take over The Wyatt Sicks in Uncle Howdy's absenceUncle Howdy has been notably absent from The Wyatt Sicks faction. There is no official clarification yet from the Triple H creative team regarding his disappearance from television. However, in the absence of the masked man, Nikki Cross might step up and become the new leader of the horror faction.Nikki Cross is playing a crucial role in The Wyatt Sicks. With Uncle Howdy's absence, she seems like a perfect fit to lead the faction on the blue brand.#3. Nia Jax and Candice LeRae could reuniteCandice LeRae is also not part of television right now. Recently, reports indicated she has taken on a new backstage role as a producer. Even so, if WWE has plans to bring her back on TV, Candice might team up with Nia Jax on SmackDown before Saturday Night's Main Event.Alexa Bliss is already set to face The Irresistible Force on SmackDown. So, Candice might return on the Nick Aldis show and help Jax to defeat the Women's Tag Team Champion.#2. Damian Priest could introduce his girlfriend on WWE SmackDownOver the past few weeks, Damian Priest has been struggling with the numbers game against Aleister Black, as the former AEW star has Zelina Vega on his side. To finally overpower Black and Vega, the former Judgment Day member might introduce his real-life girlfriend, Lola Vice, to the main roster.Currently, Lola is part of NXT, but it won't be a surprise if WWE incorporates their real-life relationship into the storyline when Vice helps Priest against the power couple.#1. Solo Sikoa might answer the WWE United States Championship open challengeTribaI Wrestling @TribalMegastarLINKSOLO SIKOA HAS ARRIVED. SO MUCH AURA 🔥🔥🔥 BRING THAT TITLE HOME SOLO 🙏 #SmackDownIlja Dragunov continues to hold the open challenge for his United States Championship, and this will likely continue on WWE SmackDown before SNME. One of the possible names who might answer the challenge this week could be Solo Sikoa.The former US Champion's distraction played a major role in Sami Zayn losing the title and The Mad Dragon becoming the new champion. Given this, Solo might finally emerge as the contender for the mid-card title by accepting the open challenge.Although a title change seems unlikely, especially since Ilja won the title just a few weeks ago.