Week 6 SNF Lions vs. Chiefs Start 'Em Sit 'Em Picks feat. Xavier Worthy, Sam LaPorta, Isiah Pacheco

Week 6 of the 2025 fantasy football season features one of the most intriguing matchups of the year on Sunday Night Football. The Kansas City Chiefs and Detroit Lions will face off in what should be an exciting game with plenty of scoring opportunities.

Both teams have plenty of lineup options this week, but here are the best ones to target and fade.

Lions vs Chiefs Fantasy Football Week 6 Start 'Em Picks

Week 6 starts

The Detroit Lions feature one of the deepest offenses in the entire NFL with a ton of legitimate weapons. One of them that has been consistently reliable in fantasy football is Sam LaPorta.

He finished his first two seasons ranked as the overall TE1 and TE7 and ranks as the TE10 this year. He's also coming off a season-best weekly finish of TE4 last week, making him an excellent tight end to use in all lineups.

Xavier Worthy is another strong option this week as the primary receiving weapon in the Kansas City Chiefs offense. Rashee Rice is suspended for one more game, so Worthy should continue to see a heavy workload until at least then. He has recorded 11 receptions on 17 targets with 172 scrimmage yards across the past two weeks.

Must Starts

• Patrick Mahomes
• Jahmyr Gibbs
• Amon-Ra St. Brown
• Xavier Worthy
• Sam LaPorta

DFS Picks

• Jared Goff
• Jameson Williams
• Travis Kelce

Lions vs Chiefs Fantasy Football Week 6 Sit 'Em Picks

Week 6 sits

The Chiefs have been waiting for Isiah Pacheco to break out, and so have his fantasy managers. He appeared to be on his way to being one of the elite running backs before suffering a leg injury last year. He has severely struggled to find consistency since then and ranks as just the RB41 this season, making him a fade against one of the best rushing defenses.

David Montgomery is another potential fade this week, especially in DFS formats. Jahmyr Gibbs has been the featured running back for the Lions, and while Montgomery has still been valuable in some weeks, facing a tough defense appears to be a bad spot for him. He already has three finishes outside of the top 25 weekly running backs and will be difficult to trust against a tough defense.

Must Sits

• Isiah Pacheco
• Kareem Hunt
• Brashard Smith
• Kalif Raymond
• JuJu Smith-Schuster
• Isaac TeSlaa
• Noah Gray
• Brock Wright

DFS Fades

• David Montgomery
• Hollywood Brown
• Tyquan Thornton