Week 15 Fantasy Football RB Rankings and Picks feat. Derrick Henry, Josh Jacobs, Christian McCaffrey, De'Von Achane

The fantasy football playoffs are here. While the conventional NFL season still has almost a month before single elimination begins, fantasy football managers now find themselves with only one shot to get their roster right, or they will lose everything they have worked for. It starts with the running backs, as the weather will set up more scenarios that favor running over throwing.

As such, Sportskeeda has compiled a list of the top running backs in fantasy football heading into Week 15. The list takes into account recent production, season-long production, and matchups. Take a look.

1. Christian McCaffrey
2. Jahmyr Gibbs
3. Bijan Robinson
4. Derrick Henry
5. Bucky Irving
6. De'Von Achane
7. Travis Etienne Jr.
8. Josh Jacobs
9. Javonte Williams
10. James Cook III
11. RJ Harvey
12. Kenneth Walker III
13. Quinshon Judkins
14. Kyle Monangai
15. Kyren Williams
16. Breece Hall
17. Rico Dowdle
18. Saquon Barkley
19. Jonathan Taylor
20. D'Andre Swift
21. Chuba Hubbard
22. TreVeyon Henderson
23. Kareem Hunt
24. Woody Marks
25. Omarion Hampton
26. Kimani Vidal
27. Ashton Jeanty
28. Bam Knight
29. Kenneth Gainwell
30. Jaylen Warren
31. Aaron Jones
32. Chase Brown
33. Blake Corum
34. Devin Neal
35. Chris Rodriguez
36. David Montgomery

Week 15 Fantasy Football RB Picks

Derrick Henry at Cincinnati Bengals v Baltimore Ravens - NFL 2025 - Source: Getty

Derrick Henry vs CIN

The Baltimore Ravens offense has been far from explosive since Lamar Jackson came back from injury, and there was not a matchup more revealing than Baltimore's first matchup against the Cincinnati Bengals on Nov. 27. However, Derrick Henry was perhaps the only functional piece of the offense, earning 60 yards and a touchdown on ten carries.

If he can receive more carries this time around (likely), he could be in for a big game against one of the weakest defenses in the NFL. Considering the Ravens gave him 25 carries on Sunday, he could see a similar workload.

Christian McCaffrey vs TEN

The San Francisco 49ers should take care of business against Cam Ward, who is playing with an interim head coach in a lost season. The contest will take place in San Francisco, which should keep the Tennessee Titans offense dragging behind the 49ers. If that happens, Christian McCaffrey should run rampant over the defense.

The Titans sit in the middle of the pack in terms of rushing defense, so it might not be McCaffrey's easiest defense of the year. However, the situation is likely to make up for it, setting the stage for a great fantasy football haul.

Saquon Barkley vs LV

Saquon Barkley has been a disappointment in fantasy football this year as a conventionally drafted top pick. However, if he's going to have a third 100-yard rushing day this season, it will most likely come in this contest.

Jalen Hurts is coming off the worst performance of his career, and Nick Sirianni has every reason to feed Barkley. Sirianni called the idea of benching Hurts "ridiculous" on 94 WIP on Wednesday via a Wednesday report from ESPN.

However, adding extra carries to help settle him down seems like a happy middle ground. The Las Vegas Raiders rushing defense is less than formidable as well, setting the stage for some breakaway runs for Barkley. Even if he doesn't have a 30-point fantasy football game, he is likely to score in the teens as he has in five games this season.