Week 15 Fantasy Football Defense Rankings and Streamers feat. San Francisco 49ers, Dallas Cowboys, and more

It's Week 15 in the fantasy football world. If you've made it this far, congratulations, but there's still a way to go. One key strategy of teams that have made it this far is to stream defenses. Another strategy has been to draft one of the best defenses early and ride them for most of the year.

However, with everything coming down to one game at a time, it is essential to optimize your chances by selecting the best matchup. To help you make the correct pick, Sportskeeda has compiled a list of the best defenses in Week 15, along with some streamable options.

Fantasy Football Defense Rankings for Week 15

Rank	Week 15 Defense	Opponent
1	Houston Texans	Arizona Cardinals
2	Seattle Seahawks	Indianapolis Colts
3	Jacksonville Jaguars	New York Jets
4	Philadelphia Eagles	Las Vegas Raiders
5	Pittsburgh Steelers	Miami Dolphins
6	Kansas City Chiefs	Los Angeles Chargers
7	San Francisco 49ers	Tennessee Titans
8	Chicago Bears	Cleveland Browns
9	Dallas Cowboys	Minnesota Vikings
10	Green Bay Packers	Denver Broncos

Fantasy Football Defense Streamers for Week 15

Robert Saleh at Carolina Panthers v San Francisco 49ers - NFL 2025 - Source: Getty

San Francisco 49ers (vs Tennessee Titans)

The San Francisco 49ers are set to face the Tennessee Titans in their own building, riding a recent hot streak on defense, earning double-digit points in each of their last two games. If Robert Saleh has figured out a scheme that works, it should pour destruction on rookie Cam Ward, who might be in for a hangover after defeating Shedeur Sanders.

The game will take place in a hostile environment for Ward as well, which should further help the unit shut down the rookie as the team aims to keep pace in a three-way NFC West race. If your fantasy football team needs to stream a defensive unit, you could do worse than San Francisco.

Chicago Bears (vs Cleveland Browns)

The Chicago Bears are set to be the biggest test yet for Shedeur Sanders. Expect the rookie quarterback to press too hard to try to keep pace with Caleb Williams, which will result in turnovers.

Quinshon Judkins has been up and down in recent weeks, so don't expect him to make much of a dent in Chicago. The game will also take place in Chicago, where the weather could further hamper the Browns offense.

According to The Weather Channel's Tuesday 10-day weather report, the temperature could drop into the single digits, which could severely slow down the offense on both sides.

Dallas Cowboys (vs Minnesota Vikings)

The Dallas Cowboys have been a team to avoid all season long on defense in fantasy football, but a rare opportunity has given the unit a chance for a quality fantasy football game. There are risks with J.J. McCarthy coming off his best game of the season, in which he threw for three touchdowns.

However, with the game taking place in Dallas, the home-field advantage should further help out the team, which should be galvanized by the Philadelphia Eagles loss to the Los Angeles Chargers on Monday Night Football in Week 14.