Week 13 Fantasy Football Defense Rankings and Streamers feat. Jacksonville Jaguars, San Francisco 49ers, and more

As many fantasy football managers are aware, it's Thanksgiving week in the NFL. As such, the byes are put on hold for a week, with football set to be on television all day on Thanksgiving, Black Friday, and on Sunday, as well as Monday Night Football. There will be no shortage of action and no shortage of defensive earning opportunities for fantasy football managers.

Here's a look at defenses fantasy football managers can consider, including teams that could be streamable.

Fantasy Football Defense Rankings for Week 13

Rank	Week 13 Defense	Opponent
1.	Los Angeles Chargers	Las Vegas Raiders
2.	Denver Broncos	Washington Commanders
3.	Jacksonville Jaguars	Tennessee Titans
4.	New England Patriots	New York Giants
5.	Cleveland Browns	San Francisco 49ers
6.	Atlanta Falcons	New York Jets
7.	San Francisco 49ers	Cleveland Browns
8.	Los Angeles Rams	Carolina Panthers
9.	New York Jets	Atlanta Falcons
10.	Miami Dolphins	New Orleans Saints

Fantasy Football Defense Streamers for Week 13

Devin Lloyd at Los Angeles Chargers v Jacksonville Jaguars - NFL 2025 - Source: Getty

#3 - Jacksonville Jaguars (at Tennessee Titans)

The Jacksonville Jaguars defense has been inconsistent this season. However, the Tennessee Titans defense has been more inconsistent. With the Titans essentially watching the clock for the rest of the year and in the midst of rebuilding, the Titans offense might beat itself. The Jaguars are seemingly on tap for a quality showing by default as a result.

The Jaguars have held opponents to a combined 30 points in their last two games. If they can keep pace and show up against the Titans like they did against the Los Angeles Chargers on Nov. 16, it could be another impressive day for the unit in terms of fantasy football production.

#2 - San Francisco 49ers (at Cleveland Browns)

This matchup will be about Shedeur Sanders more than anything else. After beating the Las Vegas Raiders in his first start, the question is whether he can take care of business against tougher competition.

The San Francisco 49ers are likely to remind Sanders that the NFL is a tough place to play, as long as Brock Purdy can avoid turnovers that hand Sanders' offense redzone looks like he did against the Carolina Panthers in Week 12.

#1 - New York Jets (vs Atlanta Falcons)

The New York Jets have not had the best defense this season by any stretch. However, against offenses with a shaky foundation, the Jets have dominated. The Jets earned 20 points against the Cleveland Browns in Week 10 and double-digits against the Denver Broncos in Week 6.

With Michael Penix Jr. out for the season and needing ACL reconstruction surgery, per Raheem Morris via ESPN on Saturday, the Atlanta Falcons find themselves on shaky offensive footing. Kirk Cousins is seemingly on deck to start, but the quarterback hasn't been consistently reliable since arguably 2022.