Week 10 Fantasy Football Defense Rankings and Streamers feat. Cleveland Browns, Buffalo Bills, and more

As fantasy football managers might already be aware, it's that time of the week again. With the conclusion of Week 9 comes the dawn of Week 10, which means it's time to start preparations for another week of games. One necessary decision is choosing your defense. Will you let it ride, or will you pick up a potentially fresh team?

Here's a look at how the Week 10 slate is shaping up for defenses, including a look at the top ten defenses and a look at those that might be streamable.

Fantasy Football Defense Rankings for Week 10

Rank	Week 10 Defense	Opponent
1	Denver Broncos	Las Vegas Raiders
2	Cleveland Browns	New York Jets
3	Buffalo Bills	Miami Dolphins
4	Carolina Panthers	New Orleans Saints
5	New York Jets	Cleveland Browns
6	New Orleans Saints	Carolina Panthers
7	Houston Texans	Jacksonville Jaguars
8	Detroit Lions	Washington Commanders
9	Jacksonville Jaguars	Houston Texans
10	New York Giants	Chicago Bears

Fantasy Football Defense Streamers for Week 10

Kansas City Chiefs v Buffalo Bills - NFL 2025 - Source: Getty

#3 - Buffalo Bills (at Miami Dolphins)

The Buffalo Bills haven't exactly been the stiff unit of yore, but when it comes to streamable defenses, it doesn't get much better than facing the sleepwalking Miami Dolphins. Miami will be hosting the game, but that didn't stop the Baltimore Ravens' questionable defense from walking over Tua Tagovailoa.

With both teams quite familiar with each other, expect the Bills to be in the best formation possible on many snaps. When players are in position, they make plays. Expect plenty of made plays against Miami.

#2 - Carolina Panthers (vs New Orleans Saints)

The Carolina Panthers managed to hold the Green Bay Packers to just 13 points on Sunday, setting the stage for a potentially even better performance against rookie Tyler Shough. The Panthers and New Orleans Saints are quite familiar with each other as neighbors in the NFC South, so the scoring should be low by default.

If the Panthers can sprinkle in some takeaways in addition to keeping a low score, they are in for a productive day in fantasy football, which is great news for managers who take the plunge.

#1 - Cleveland Browns (at New York Jets)

The Cleveland Browns have plenty of troubles, but one consistent area this season has been an impressive defense. With the New York Jets also struggling on offense thanks to an unsettled quarterback situation, the stage is set for a game that could end without a touchdown by either team.

Aaron Glenn appears to once again be playing coy about the team's starting quarterback, per a Monday CBS Sports report, but it might not matter who starts either way. Put simply, expect a defensive slugfest and the best streamable matchup of the week.