Detroit Lions vs. Dallas Cowboys predictions, odds, and picks for Week 14 TNF clash

The Dallas Cowboys and Detroit Lions are heading into an encore Thursday performance one week after playing on Thanksgiving. Both teams have settled into their brief new schedule, so expect a better-than-usual battle in prime time as the weekend approaches.

Here's a look at everything you need to know about the contest heading into the showdown.

Dallas Cowboys vs Detroit Lions: Game Details

Fixture: Dallas at Detroit on TNF

Date & Time: Thursday, Dec. 4, 2025 at 8:15 PM EST

Venue: Ford Field in Detroit, Michigan

Dallas Cowboys vs Detroit Lions: Betting Odds (via BetMGM)

Spread

Dallas (+3)

Detroit (-3)

Moneyline

Dallas (+140)

Detroit (-165)

Total

Over/Under (54.5)

Dallas Cowboys vs Detroit Lions: Picks

Jared Goff at Green Bay v Detroit - Source: Getty

This week, the most interesting bets are to take the anytime touchdown for Dak Prescott and Jared Goff. Prescott has thrown at least one touchdown in all but two games this season. Goff, meanwhile, has thrown a touchdown in every game this season.

With the game likely to be a shootout, there's no reason to think the pattern is going to change, especially after settling into the second of two Thursday games.

Dallas Cowboys vs Detroit Lions: NFL Injury Report

Dallas

OT Tyler Guyton (Ankle) - Out

DE Jadeveon Clowney (Hamstring) - Questionable

CB Trevon Diggs (Knee) - Out

Detroit

S Kerby Joseph (Knee) - Out

WR Khalif Raymond (Ankle) - Out

TE Brock Wright (Neck) - Out

TE Shane Zylstra (Knee) - Out

G Kayode Awosika (Foot) - Questionable

DB Brian Branch (Toe/Ankle) - Questionable

T Taylor Decker (Shoulder/Rest) - Questionable

OL Graham Glasgow (Knee) - Questionable

T Penei Sewell (Shoulder) - Questionable

WR Amon-Ra St. Brown (Ankle) - Questionable

RB Sione Vaki (Thumb) - Questionable

Dallas Cowboys vs Detroit Lions: Head-to-Head

The Dallas Cowboys lead the all-time series 19-13 in a rivalry that dates back to 1960. Dallas has scored 799 points, outscoring Detroit's 639 points. However, Dallas has been on a particularly big roll, winning six of the last seven contests.

Of course, Detroit dismantled Dallas in their most recent matchup on Oct. 13, 2024, when the team won 47-9. Dak Prescott played in that contest, giving Detroit fans a reason to have confidence heading into the matchup.

Dallas vs Detroit: Prediction for Week 14

Dallas might be coming off one of the worst losses in the series' history, but the addition of George Pickens and the promotion of Brian Schottenheimer make things completely different. Dak Prescott's offense has a new layer of surprise that it didn't have in 2024.

As such, expect Dallas to test Detroit. However, Detroit will win the contest with the added boost of home-field advantage. Expect Detroit to win 35-31.