Buffalo Bills vs. Houston Texans predictions, odds, and picks for Week 12 TNF clash

The Buffalo Bills and Houston Texans are set to square off in what should be an entertaining affair on Thursday Night Football. Of course, many more than just Bills and Texans fans will be tuning in with their various ulterior motives.

As such, Sportskeeda has compiled everything you need to know about the game heading into the contest, including odds, picks, predictions, game details, and more.

Buffalo Bills vs. Houston Texans: Game Details

Fixture: Bills at Texans on TNF

Date & Time: Thursday, Nov. 20 at 8:15 PM EST

Venue: NRG Stadium

Buffalo Bills vs. Houston Texans: Betting Odds (via BetMGM)

Spread

Bills (-6)

Texans (+6)

Moneyline

Bills (-285)

Texans (+230)

Total

Over/Under (43.5)

Buffalo Bills vs. Houston Texans: Picks

Josh Allen at Tampa Bay v Buffalo - NFL 2025 - Source: Getty

One interesting bet is the anytime touchdown for Josh Allen. As the team's quarterback, he has a solid chance by default. He also has not gone without a passing touchdown since Sept. 14. Considering Allen's ability to score with his legs, there is still a high chance of scoring on the ground even if his nearly season-long streak comes to an end.

Another bet to consider is the James Cook anytime touchdown. If the Bills get to the goal line without scoring, Cook is a candidate to receive the ball as the team's leading back before anyone else aside from Allen. If you're feeling lucky, you can consider going for both for double the wins.

Buffalo Bills vs. Houston Texans: NFL Injury Report

Buffalo

TE Dalton Kincaid (Hamstring) - Out

DT Phidarian Mathis (Shoulder) - Questionable

WR Mecole Hardman (Calf) - Out

WR Curtis Samuel (Elbow/Neck) - Out

Houston

LB Jamal Hill (Hamstring) - Out

S Jalen Pitre (Concussion) - Out

QB C.J. Stroud (Concussion) - Out

Buffalo Bills vs. Houston Texans: Head-to-Head

The rivalry between Buffalo and the Houston Texans is still quite young, with only 12 games in NFL history between the two franchises. Houston leads the series 7-5, dating back to their first matchup on Oct. 13, 2002.

While Houston leads the series in wins and losses, Buffalo has scored more points in total, 245 to 225. Could Buffalo pull the series within one game and maintain the lead in total points scored?

Buffalo Bills vs. Houston Texans: Prediction for Week 12

Buffalo has two stars: Josh Allen and James Cook. Buffalo will need the best from both to pull out a win against the stiff Houston Texans defense.

If Davis Mills can avoid an early implosion under the spotlight, the game should go all four quarters. Expect some heroics from Allen and one or two notable plays from Cook.

Buffalo will win a tight contest with plenty of twists and turns by a score of 24-17.