UFC Fight Night: Santos vs. Walker is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 2, 2021 at the UFC APEX, Las Vegas United States.
Main Card
| Weight Class | Fight | Method | Round | Results |
| Light Heavyweight | Thiago Santos vs. Johnny Walker | Decision | R5 (05:00) | Thiago Santos def. Johnny Walker |
| Middleweight | Kevin Holland vs. Kyle Daukaus | Other | R1 (03:43) | Draw |
| Welterweight | Alex Oliveira vs. Niko Price | Decision | R3 (05:00) | Niko Price def. Alex Oliveira |
| Middleweight | Misha Cirkunov vs. Krzysztof Jotko | Decision | R3 (05:00) | Krzysztof Jotko def. Misha Cirkunov |
| Lightweight | Alexander Hernandez vs. Mike Breeden | KO/TKO | R1 (01:20) | Alexander Hernandez def. Mike Breeden |
Preliminary Card
| Weight Class | Fight | Method | Round | Results |
| Lightweight | Joe Solecki vs. Jared Gordon | Decision | R3 (05:00) | Jared Gordon def. Joe Solecki |
| Women Flyweight | Antonina Shevchenko vs. Casey O'Neill | KO/TKO | R2 (04:47) | Casey O'Neill def. Antonina Shevchenko |
| Women Bantamweight | Bethe Correia vs. Karol Rosa | Decision | R3 (05:00) | Karol Rosa def. Bethe Correia |
| Lightweight | Devonte Smith vs. Jamie Mullarkey | KO/TKO | R2 (02:51) | Jamie Mullarkey def. Devonte Smith |
| Bantamweight | Douglas Silva de Andrade vs. Gaetano Pirrello | KO/TKO | R1 (02:04) | Douglas Silva de Andrade def. Gaetano Pirrello |
| Women Bantamweight | Stephanie Egger vs. Shanna Young | KO/TKO | R2 (02:22) | Stephanie Egger def. Shanna Young |
| Bantamweight | Alejandro Pérez vs. Johnny Eduardo | Submission | R2 (04:13) | Alejandro Pérez def. Johnny Eduardo |
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