UFC Fight Night: Holloway vs. Rodriguez is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on November 13, 2021 at UFC Apex in Las Vegas, United States.
Main Card
| Weight Class | Fight | Method | Round | Results |
| Featherweight | Max Holloway vs. Yair Rodriguez | Decision | R5 (05:00) | Max Holloway def. Yair Rodriguez |
| Heavyweight | Ben Rothwell vs. Marcos Rogério de Lima | KO/TKO | R1 (00:32) | Marcos Rogério de Lima def. Ben Rothwell |
| Women's Featherweight | Felicia Spencer vs. Leah Letson | KO/TKO | R3 (04:25) | Felicia Spencer def. Leah Letson |
| Welterweight | Miguel Baeza vs. Kalinn Williams | KO/TKO | R3 (01:02) | Kalinn Williams def. Miguel Baeza |
| Bantamweight | Song Yadong vs. Julio Arce | KO/TKO | R2 (01:35) | Song Yadong def. Julio Arce |
Preliminary Card
| Weight Class | Fight | Method | Round | Results |
| Lightweight | Thiago Moisés vs. Joel Alvarez | KO/TKO | R1 (03:01) | Joel Alvarez def. Thiago Moisés |
| Women Flyweight | Cynthia Calvillo vs. Andrea Lee | KO/TKO | R2 (05:00) | Andrea Lee def. Cynthia Calvillo |
| Featherweight | Sean Woodson vs. Collin Anglin | KO/TKO | R1 (04:30) | Sean Woodson def. Collin Anglin |
| Women Flyweight | Cortney Casey vs. Liana Jojua | Decision | R3 (05:00) | Cortney Casey def. Liana Jojua |
| Lightweight | Marc Diakiese vs. Rafael Alves | Submission | R1 (01:48) | Rafael Alves def. Marc Diakiese |
| Light Heavyweight | Kennedy Nzechukwu vs. Jung Da Un | KO/TKO | R1 (03:04) | Jung Da Un def. Kennedy Nzechukwu |
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