Chicago Bulls vs Detroit Pistons Prediction and Preview - Nov. 12 | 2025-26 NBA Season

Following a lone-game homestand, the Chicago Bulls are set to begin their four-game road trip with the first stop in Michigan. Wednesday’s contest at the Detroit Pistons marks their second out of four meetings between the teams in the 2025-2026 regular season.

Chicago Bulls vs. Detroit Pistons Preview, Odds, Betting Tips and Prediction

The Bulls-Pistons clash is set to tip off at 7 p.m. ET (4 p.m. PT). The live telecast will be available on CHSN and FDSDET. Fans can watch the contest via livestream on NBA League Pass (restrictions may apply).

Moneyline: Bulls (+114) vs Pistons (-135)

Odds: Bulls (+2.5 -110) vs Pistons (-2.5 -110)

Total (O/U): Bulls (o234.5 -108) vs Pistons (u234.5 -112)

Editor’s Note: The odds could change closer to the game. The odds listed are based on available information at the time of publication.

Chicago Bulls vs. Detroit Pistons Preview

The Chicago Bulls and Detroit Pistons tipped off their 2025-2026 season with an entertaining matchup that also marked their first meeting of the campaign. The Bulls’ dynamic duo of Josh Giddey and Nikola Vucevic led the charge with impressive double-doubles. Giddey put up 19 points and 11 assists, while Vucevic dominated the paint with 28 points and 14 rebounds.

Although the Pistons suffered a 115-111 loss, there were plenty of positive takeaways. Cade Cunningham notched a 23-point, 10-assist double-double, and Isaiah Stewart made a huge impact off the bench, contributing 20 points and 11 rebounds.

Heading into Wednesday’s game, Detroit looks much improved, having won seven straight with an average margin of victory of 11.0 points per game.

The Bulls, meanwhile, are struggling through a three-game losing streak. They dropped both games on their recent road trip against Milwaukee and Cleveland. Subsequently, they lost 121-117 to the San Antonio Spurs at home on Monday.

Chicago Bulls vs. Detroit Pistons Predicted Starting 5s

Bulls starting 5

G: Josh Giddey | G: Ayo Dosunmu | F: Isaac Okoro | F: Matas Buzelis | C: Nikola Vucevic

Pistons starting 5

G: Cade Cunningham | G: Duncan Robinson | F: Javonte Green | F: Ronald Holland II | C: Jalen Duren

Chicago Bulls vs. Detroit Pistons betting tips

• Josh Giddey O/U 7.5 assists - Take the over
• Cade Cunningham O/U 29.5 points - Take the over
• Jalen Duren O/U 13.5 rebounds - Take the under
• Nikola Vucevic O/U 18.5 points - Take the under

Chicago Bulls vs. Detroit Pistons Prediction

The Chicago Bulls are in a rough stretch, with a three-game losing streak heading into their matchup against the Pistons, who hold the best record in the Eastern Conference.

Detroit’s roster runs deep, and several players besides Cade Cunningham have shown they can take over a game with strong scoring performances.

The Pistons are dealing with a few injuries, as Ausar Thompson, Tobias Harris and Isaiah Stewart are all expected to be out. That could give the Bulls a chance to keep things competitive. However, Detroit should have enough firepower to secure the victory.

Prediction: Expect the Pistons to win by six points.