Yankees vs. Red Sox: Game 3 prediction, lineup, odds, injuries, and picks

The American League Wild Card Series between the New York Yankees and the Boston Red Sox is perfectly set up for a historic night at Yankee Stadium on Wednesday. After the Red Sox pulled off a Game 1 win, the Yankees rebounded in Game 2, with a go-ahead RBI by Austin Wells in the bottom of the eighth securing the win.

Yankees vs. Red Sox Game 3 ALWS: Betting Odds and Weather

Time: 8:08 p.m. EDT at Yankee Stadium

Money Line: Yankees -162, Red Sox +136

Total Runs: Over/Under is 7.5 runs

Weather: Clear, 62 degrees F, 0% precipitation, Wind 5 mph R-L

Yankees vs. Red Sox Game 3 ALWS: Injuries and Lineups

Injuries

Yankees

Brent Headrick: 15-Day IL (forearm),
Jonathan Loaisiga: 15-Day IL (back),
Clarke Schmidt: 60-Day IL (forearm),
Oswaldo Cabrera: 60-Day IL (ankle),
Jake Cousins: 60-Day IL (elbow),
Gerrit Cole: 60-Day IL (elbow)

Red Sox

Dustin May: 15-Day IL (elbow),
Richard Fitts: 15-Day IL (arm),
Jordan Hicks: 15-Day IL (shoulder),
Brennan Bernardino: 15-Day IL (lat),
Roman Anthony: 10-Day IL (oblique),
Vaughn Grissom: 60-Day IL (foot),
Hunter Dobbins: 60-Day IL (ACL),
Marcelo Mayer: 60-Day IL (wrist),
Luis Guerrero: 60-Day IL (elbow),
Tanner Houck: 60-Day IL (flexor),
Liam Hendriks: 60-Day IL (hip),
Josh Winckowski: 60-Day IL (elbow),
Triston Casas: 60-Day IL (knee),
Kutter Crawford: 60-Day IL (knee),
Patrick Sandoval: 60-Day IL (elbow)

Expected Lineups

Yankees

1B P. Goldschmidt R
RF Aaron Judge R
CF C. Bellinger L
DH G. Stanton R
3B Amed Rosario R
LF A. Slater R
2B J. Chisholm L
SS A. Volpe R
C Austin Wells L

Red Sox

LF Jarren Duran L
SS Trevor Story R
3B Alex Bregman R
DH M. Yoshida L
2B R. Gonzalez R
1B N. Lowe L
RF Wilyer Abreu L
C C. Narvaez R
CF C. Rafaela R

Yankees vs. Red Sox Game 3 ALWS: Expert Picks and Prediction

The matchup will feature two fresh faces as Connelly Early (1-2, 2.33 ERA) of the Red Sox will face fellow rookie Cam Schlittler (4-3, 2.96 ERA) in the third-youngest pitching duel in a deciding game in MLB history. Schlittler has logged 10 more starts than Early.

Both lineups were silent in the first two games while the pitching staffs continued to deliver. The Red Sox have a 2.79 ERA while the Bombers are at 2.08 ERA in their last 10 games.

Superstars Aaron Judge, Giancarlo Stanton and Alex Bregman will be itching to make a mark.

Prediction: Yankees 5, Red Sox 4

Picks: Yankees ML (-162), Over 7.5 runs

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by R. Nikhil Parshy

Yankees vs. Red Sox: Game 3 prediction, lineup, odds, injuries, and picks - October 02, 2025| AL Wild Card Series

Yankees vs. Red Sox Game 3 ALWS: Betting Odds and Weather

Yankees vs. Red Sox Game 3 ALWS: Injuries and Lineups

Injuries

Yankees

Red Sox

Expected Lineups

Yankees

Red Sox

Yankees vs. Red Sox Game 3 ALWS: Expert Picks and Prediction